Description

D-Valine, 4-Fluoro-3-Hydroxy-, (3S)- (9Ci) is a non-natural, fluorinated amino acid derivative of high synthetic value. This chiral building block is essential for the development of novel pharmaceuticals and bioactive compounds, particularly in the fields of protease inhibitors and peptide-based therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated and hydroxylated amino acid motifs, altering peptide stability and bioactivity.
• Medicinal Chemistry Research: Serves as a critical building block in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Biochemical Tool: Can be used to study enzyme mechanisms and substrate specificity, particularly for enzymes that process valine or fluorinated analogues.
• Agrochemical Research: Potential intermediate in the development of advanced, bioactive compounds for crop protection.

Basic Information

Product Name	D-Valine, 4-Fluoro-3-Hydroxy-, (3S)- (9Ci)
CAS No.	737738-68-0
Molecular Formula	C5H10FNO3
Molecular Weight	151.14 g/mol
Synonyms	(3S)-4-Fluoro-3-hydroxy-D-valine; D-4-Fluoro-3-hydroxyvaline; (2S)-2-Amino-3-fluoro-4-hydroxy-3-methylbutanoic acid; (3S)-4-Fluoro-3-hydroxyvaline, D-; 737738-68-0; 4-Fluoro-3-hydroxy-D-valine; D-3-Hydroxy-4-fluorovaline
EINECS	Contact for details

Quality Control

Our D-Valine, 4-Fluoro-3-Hydroxy-, (3S)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.