Description

Propanedinitrile, (1R,2R,4S)-Bicyclo[2.2.1]Hept-2-Yl-2-Propenyl-, Rel- (9Ci) is a specialized chiral nitrile derivative featuring a norbornane (bicyclo[2.2.1]heptane) core, which imparts significant structural rigidity and stereochemical definition. This compound matters as a high-value chemical building block and advanced pharmaceutical intermediate for the synthesis of complex, biologically active molecules. It is primarily needed by research institutions and industrial R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors, where precise stereochemistry and functional group compatibility are critical for developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides where the norbornane scaffold contributes to target specificity and environmental stability.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enhancing reaction selectivity and yield.
• Advanced Material Research: Employed in the synthesis of monomers for specialty polymers with unique thermal and mechanical properties, such as high-performance resins and liquid crystals.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry, enabling studies on cycloaddition reactions and stereoselective transformations.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex fragrance compounds and other high-value specialty chemicals.

Basic Information

Product Name	Propanedinitrile, (1R,2R,4S)-Bicyclo[2.2.1]Hept-2-Yl-2-Propenyl-, Rel- (9Ci)
CAS No.	736992-86-2
Molecular Formula	C13H16N2
Molecular Weight	200.28 g/mol
Synonyms	rel-(1R,2R,4S)-2-(2-Propenyl)bicyclo[2.2.1]heptane-2-propanedinitrile; (1R,2R,4S)-2-Allylbicyclo[2.2.1]heptane-2-acetonitrile; Norbornane-based chiral dinitrile; Bicyclo[2.2.1]hept-2-yl-2-propenylpropanedinitrile; Chiral norbornyl allyl dinitrile; (1R,2R,4S)-2-(Allyl)-2-(cyanomethyl)bicyclo[2.2.1]heptane; CAS 736992-86-2
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and impurity profiles. We support cGMP compliance for pharmaceutical development and can tailor specifications to meet specific research or project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert atmosphere conditions to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.