Description

3-Hydroxyanagrelide is a key pharmaceutical intermediate and metabolite of the active pharmaceutical ingredient Anagrelide. This compound matters for its critical role in the development, quality control, and metabolic study of therapeutic agents used to treat thrombocythemia. It is primarily needed by pharmaceutical manufacturers and research institutions focused on hematological disorders, serving as a high-purity reference standard and a building block for advanced drug synthesis.

Application

• Pharmaceutical Intermediate: A crucial synthetic precursor in the production of Anagrelide hydrochloride and related therapeutic compounds.
• Analytical Reference Standard: Used in quality control laboratories for the identification and quantification of Anagrelide and its metabolites via HPLC, LC-MS, or other chromatographic methods.
• Metabolite Research: Essential for pharmacokinetic and pharmacodynamic studies to understand the metabolism, efficacy, and safety profile of Anagrelide.
• Impurity Standard: Employed as a certified impurity standard to monitor and control the quality of Anagrelide active pharmaceutical ingredient (API) batches according to ICH guidelines.
• Biochemical Research: Used in in-vitro studies to investigate mechanisms of action related to platelet reduction and megakaryocyte maturation.
• Custom Synthesis: Serves as a starting material for the research and development of novel analogs and derivatives with potential improved therapeutic profiles.

Basic Information

Product Name	3-Hydroxyanagrelide
CAS No.	733043-41-9
Molecular Formula	C10H7Cl2N3O
Molecular Weight	256.09 g/mol
Synonyms	6,7-Dichloro-3-hydroxy-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one; Anagrelide Impurity F; Anagrelide Metabolite; 3-OH-Anagrelide; 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one, 3-hydroxy-; UNII-9G2C6S6B6F; Anagrelide Related Compound F
EINECS	Contact for details

Quality Control

Our 3-Hydroxyanagrelide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, assay, and impurity profiles. We support compliance with ICH Q3A/B guidelines for impurities in new drug substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under inert atmosphere to maintain stability. Keep the container tightly sealed in a dry environment to protect this moisture-sensitive compound.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.