Description

Anagrelide is a potent and selective inhibitor of megakaryocyte proliferation and differentiation. This pharmaceutical active ingredient is critical for the targeted management of specific hematological disorders, offering a mechanism of action distinct from other therapeutic agents. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of prescription medications. Anagrelide CAS NO 68475-42-3 represents a high-value compound where supply chain reliability and stringent quality control are paramount for end-product efficacy and safety.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of oral medications for the treatment of essential thrombocythemia and related myeloproliferative disorders.
• Pharmaceutical Research & Development: Serves as a key reference standard and investigational compound in preclinical and clinical studies for hematology-oncology.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent versions of anagrelide hydrochloride medications.
• Biochemical Research: Used as a tool compound in laboratory studies to investigate platelet production, megakaryocyte biology, and cellular signaling pathways.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs engaged in the production of finished dosage forms for global pharmaceutical clients.

Basic Information

Product Name	Anagrelide
CAS No.	68475-42-3
Molecular Formula	C10H7Cl2N3O
Molecular Weight	256.09 g/mol
Synonyms	6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one; BL-4162A; Anagrelide Base; Anagrelidum; Anagrelida; Agrylin (as hydrochloride salt); Thromboreductin
EINECS	Contact for details

Quality Control

Our Anagrelide is manufactured and tested under a strict quality management system. Each batch is analyzed to meet rigorous specifications for identity, purity, and impurity profiles, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from tests including HPLC assay, related substances, residual solvents, and heavy metals. We support compliance with cGMP standards for pharmaceutical ingredient supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.