Description

Avatrombopag Hydrochloride is a potent, orally bioavailable thrombopoietin receptor agonist (TPO-RA) used as an active pharmaceutical ingredient (API). Its primary value lies in stimulating platelet production, making it a critical component for treating thrombocytopenia in patients with chronic liver disease or chronic immune thrombocytopenia (ITP). This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing and producing targeted hematology medications. Global demand is driven by its efficacy in managing low platelet counts prior to medical procedures.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of thrombocytopenia.
• Chronic Liver Disease: Manufacture of medications to treat thrombocytopenia in adult patients with chronic liver disease scheduled to undergo a procedure.
• Chronic Immune Thrombocytopenia (ITP): Production of therapies for increasing platelet counts in adult patients with chronic ITP who have had an insufficient response to previous treatment.
• Drug Substance Synthesis: Serves as a key intermediate or final bulk substance in cGMP-compliant pharmaceutical synthesis.
• Clinical Research: Utilization in preclinical and clinical studies for new hematological indications or formulation development.
• Reference Standard: Sourcing of high-purity material for use as an analytical reference standard in quality control laboratories.

Basic Information

Product Name	Avatrombopag Hydrochloride
CAS No.	570403-17-7
Molecular Formula	C29H34Cl2N6O3S2 • HCl
Molecular Weight	666.1 g/mol
Synonyms	Avatrombopag HCl; 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid hydrochloride; E5501; YM477; AKR-501; Doptelet® (brand name salt form)
EINECS	Contact for details

Quality Control

Our Avatrombopag Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters. We support compliance with global regulatory standards, including cGMP, for pharmaceutical ingredient supply.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), or as indicated on the certificate of analysis. The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.