Description

Avatrombopag is a potent, orally bioavailable, small-molecule thrombopoietin receptor agonist. This compound is critical for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure. As a targeted therapeutic agent, it is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development and production of advanced hematology treatments.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of finished dosage forms for the treatment of thrombocytopenia.
• Pharmaceutical R&D: Serves as a key reference standard and starting material in preclinical and clinical research for hematologic disorders.
• Generic Drug Manufacturing: Essential for companies developing bioequivalent versions of branded thrombopoietin receptor agonist medications.
• Clinical Trial Material: Used in the production of investigational medicinal products for new therapeutic studies.
• Contract Manufacturing: Supplied to CDMOs for scale-up and commercial production under cGMP guidelines.

Basic Information

Product Name	Avatrombopag
CAS No.	570406-98-3
Molecular Formula	C29H34Cl2N6O3S2
Molecular Weight	665.66 g/mol
Synonyms	E5501; YM477; Avatrombopag maleate (salt form); 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid; Doptelet (brand name); Thrombopoietin receptor agonist; TPO-RA; SB-497115-GR (developmental code)
EINECS	Contact for details

Quality Control

Our Avatrombopag is manufactured and tested under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical applications, supported by comprehensive analytical data. A Certificate of Analysis (COA) is provided with each batch, detailing specifications for identity, purity, and impurities as per ICH guidelines. We can support development with material compliant with current Good Manufacturing Practice (cGMP) standards for advanced clinical and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm
Loss on Drying	≤1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.