Description

Avatrombopag Maleate is a high-purity, non-peptide thrombopoietin receptor agonist used as a key active pharmaceutical ingredient (API). Its primary commercial value lies in the treatment of thrombocytopenia in adult patients with chronic liver disease scheduled to undergo a procedure. This compound is essential for pharmaceutical manufacturers and research institutions developing targeted therapies for blood platelet disorders.

Application

• Pharmaceutical API: Primary use as the active ingredient in commercial drug formulations for thrombocytopenia.
• Chronic Liver Disease (CLD) Treatment: Manufacture of medications to increase platelet counts in CLD patients prior to medical procedures.
• Chronic Immune Thrombocytopenia (ITP) Treatment: Production of therapies for patients with ITP who have had an insufficient response to previous treatment.
• Clinical Research: Utilization as a reference standard or investigational material in hematology and oncology studies.
• Drug Development: Serves as a critical intermediate or final compound in the R&D pipeline for new thrombopoietin mimetics.
• Generic Drug Manufacturing: Sourcing of the API for the production of bioequivalent generic versions following patent expiry.

Basic Information

Product Name	Avatrombopag Maleate
CAS No.	677007-74-8
Molecular Formula	C29H34Cl2N6O3S2 • C4H4O4
Molecular Weight	765.73 g/mol (for the maleate salt)
Synonyms	Avatrombopag Maleate Salt; AVA; YM477; YM-477; 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid maleate salt; (2Z)-But-2-enedioic acid;1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our Avatrombopag Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing results for tests such as HPLC assay, related substances, residual solvents, and heavy metals is provided with every shipment to guarantee traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.