Description

Eltrombopag Olamine is a small molecule thrombopoietin receptor agonist used in the treatment of thrombocytopenia. This active pharmaceutical ingredient (API) is critical for stimulating the production of platelets in patients with chronic immune thrombocytopenia (ITP) and other related conditions. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of targeted hematology medications.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of oral thrombopoietin receptor agonist medications.
• Treatment of chronic immune thrombocytopenia (ITP) in adult and pediatric patients.
• Treatment of severe aplastic anemia in patients who have had an insufficient response to immunosuppressive therapy.
• Treatment of thrombocytopenia in patients with chronic hepatitis C to allow the initiation and maintenance of interferon-based therapy.
• Key intermediate in advanced pharmaceutical research and development for hematologic disorders.
• Reference standard in analytical laboratories for quality control and method development.
• Use in preclinical and clinical studies investigating new therapeutic applications for thrombopoietin mimetics.

Basic Information

Product Name	Eltrombopag Olamine
CAS No.	496775-62-3
Molecular Formula	C25H22N4O4 • C2H7NO
Molecular Weight	564.65 g/mol (as olamine salt)
Synonyms	Eltrombopag ethanolamine; SB-497115-GR; Promacta (brand name); Revolade (brand name); 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid - 2-aminoethanol (1:1); Thrombopoietin receptor agonist; TPO-RA; SB497115
EINECS	Contact for details

Quality Control

Our Eltrombopag Olamine is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure it meets the highest standards for pharmaceutical use. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with current Good Manufacturing Practice (cGMP) guidelines and relevant pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.