Description

Eltrombopag CAS NO 496775-61-2 is a potent, orally bioavailable small molecule thrombopoietin receptor agonist. This compound is critical for stimulating the production and maturation of megakaryocytes, leading to increased platelet counts. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of treatments for thrombocytopenia, particularly in patients with chronic immune thrombocytopenia (ITP) and hepatitis C.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of thrombopoietin receptor agonist medications.
• Research and development of novel therapies for chemotherapy-induced thrombocytopenia.
• Clinical studies targeting platelet disorders like aplastic anemia and myelodysplastic syndromes.
• Formulation development for oral solid dosage forms (e.g., tablets).
• Reference standard for analytical method development and quality control in pharmaceutical labs.
• Biochemical research into megakaryopoiesis and platelet production pathways.

Basic Information

Product Name	Eltrombopag
CAS No.	496775-61-2
Molecular Formula	C25H22N4O4
Molecular Weight	442.47 g/mol
Synonyms	Eltrombopag Olamine; SB-497115; SB-497115-GR; Promacta (trade name); Revolade (trade name); 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid; Thrombopoietin receptor agonist; TPO receptor agonist
EINECS	Contact for details

Quality Control

Our Eltrombopag is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with ICH Q7 guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.