Description

2-Bromo-5-(Trifluoromethyl)Phenylacetonitrile, 97% is a high-purity, multi-functional organic intermediate featuring both bromine and trifluoromethyl substituents on a benzonitrile core. This compound is valued for its versatility in advanced synthesis, where the bromine atom serves as a handle for cross-coupling reactions and the electron-withdrawing cyano and trifluoromethyl groups direct further functionalization. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules, including active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form biaryl and other complex structures.
• Chemical Research & Development: A versatile reagent for academic and industrial research in organic synthesis, fluorochemistry, and methodology development.
• Ligand and Catalyst Development: Potential starting material for synthesizing novel phosphine or nitrogen-based ligands used in homogeneous catalysis.

Basic Information

Product Name	2-Bromo-5-(Trifluoromethyl)Phenylacetonitrile, 97%
CAS No.	732306-26-2
Molecular Formula	C9H5BrF3N
Molecular Weight	264.04 g/mol
Synonyms	(2-Bromo-5-(trifluoromethyl)phenyl)acetonitrile; 2-Bromo-α,α,α-trifluoro-m-toluonitrile; 2-Bromo-5-(trifluoromethyl)benzyl cyanide; α-Cyano-2-bromo-5-(trifluoromethyl)toluene; 2-Bromo-5-trifluoromethylphenylacetonitrile; [2-Bromo-5-(trifluoromethyl)phenyl]acetonitrile; m-(Trifluoromethyl)-2-bromobenzyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to confirm identity and assay. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. This material is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere if specified for optimal long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.