Description

2H-Isoindole-2-Acetamide, 1,3-Dihydro-1,3-Dioxo-n-(2,2,2-Trifluoroethyl)- is a specialized heterocyclic building block featuring an isoindole-1,3-dione (phthalimide) core functionalized with a trifluoroethyl amide group. This compound is valued for its unique molecular architecture, which combines a robust, planar scaffold with the strong electron-withdrawing and lipophilicity-enhancing properties of the trifluoroethyl moiety. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for use as a key intermediate in the synthesis of novel active ingredients, particularly those targeting central nervous system and metabolic disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those requiring the incorporation of a trifluoroethyl group to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the isoindoledione core can contribute to photostability and the trifluoroethyl group enhances leaf penetration and systemic activity.
• Material Science & Organic Electronics: Acts as a building block for constructing advanced organic semiconductors, dyes, and photoactive materials due to its electron-accepting characteristics and planar structure.
• Chemical Biology & Proteomics: Can be utilized as a scaffold for designing enzyme inhibitors or activity-based probes, leveraging the reactive imide group for further functionalization.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in organic synthesis, including cross-coupling reactions and amide bond formation.

Basic Information

Product Name	2H-Isoindole-2-Acetamide, 1,3-Dihydro-1,3-Dioxo-n-(2,2,2-Trifluoroethyl)-
CAS No.	732294-41-6
Molecular Formula	C12H9F3N2O3
Molecular Weight	286.21 g/mol
Synonyms	N-(2,2,2-Trifluoroethyl)phthalimide-2-acetamide; 2-[(2,2,2-Trifluoroethyl)carbamoyl]methyl]isoindole-1,3-dione; 1,3-Dioxo-2H-isoindole-2-acetic acid 2,2,2-trifluoroethylamide; Trifluoroethylphthalimide acetamide; 2-(1,3-Dioxoisoindolin-2-yl)-N-(2,2,2-trifluoroethyl)acetamide; 732294-41-6; TFEPA
EINECS	Contact for details

Quality Control

Every batch of 2H-Isoindole-2-Acetamide, 1,3-Dihydro-1,3-Dioxo-n-(2,2,2-Trifluoroethyl)- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, which is critical for your research and process scale-up. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including results from HPLC, NMR, and mass spectrometry. Our quality protocols are designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect purity and stability. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.