Description

4-Bromo-1-Methanesulfonyl-2-(Trifluoromethoxy)Benzene is a high-purity, multi-functional aromatic building block designed for advanced chemical synthesis. This compound is valued for its unique combination of bromo, methanesulfonyl, and trifluoromethoxy substituents, which impart significant reactivity and physicochemical properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, including potential active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a versatile precursor for creating advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethoxy group.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Sulfone Chemistry: The methanesulfonyl group can act as a directing group, a protecting group, or be further functionalized, enabling diverse synthetic pathways.
• Fluorine Chemistry Building Block: The trifluoromethoxy moiety provides metabolic stability and lipophilicity, making it valuable for optimizing the pharmacokinetic properties of lead compounds.

Basic Information

Product Name	4-Bromo-1-Methanesulfonyl-2-(Trifluoromethoxy)Benzene
CAS No.	731018-69-2
Molecular Formula	C8H6BrF3O3S
Molecular Weight	319.10 g/mol
Synonyms	1-Bromo-4-methanesulfonyl-2-(trifluoromethoxy)benzene; 2-(Trifluoromethoxy)-4-bromobenzene-1-sulfonylmethane; 4-Bromo-2-(trifluoromethoxy)phenyl methyl sulfone; 4-Bromo-α,α,α-trifluoro-2-methanesulfonylphenetole; 4-Bromo-1-(methylsulfonyl)-2-(trifluoromethoxy)benzene; 2-Trifluoromethoxy-4-bromophenyl methyl sulfone; Benzene, 4-bromo-1-methanesulfonyl-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Methanesulfonyl-2-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong oxidizing agents, strong bases, and sources of heat.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.