Description

Dabcyl-Lys-Hcov-Sars Replicase Polyprotein 1Ab (3235-3246)-Glu-Edans is a specialized, high-purity synthetic peptide substrate designed for protease activity assays. This compound is a critical tool for biochemical research, enabling the study of viral enzyme kinetics and inhibitor screening. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic researchers focused on virology and infectious disease mechanisms.

Application

• Protease Activity Assays: A fluorogenic substrate for the quantitative measurement of SARS-CoV replicase polyprotein 1ab protease (3CLpro) activity.
• High-Throughput Screening (HTS): Used in automated platforms to identify and characterize potential antiviral compounds and protease inhibitors.
• Enzyme Kinetic Studies: Essential for determining kinetic parameters (Km, Vmax, kcat) of viral proteases in mechanistic research.
• Diagnostic Development: Serves as a key component in the development of fluorescence-based diagnostic tests for viral enzyme detection.
• Biochemical Research: A fundamental reagent for studying coronavirus replication and the function of non-structural proteins.
• Quality Control: Employed as a reference standard in the production and validation of other diagnostic or research reagents.

Basic Information

Product Name	Dabcyl-Lys-Hcov-Sars Replicase Polyprotein 1Ab (3235-3246)-Glu-Edans
CAS No.	730985-86-1
Molecular Formula	C84H118N20O27S2
Molecular Weight	1880.1 g/mol
Synonyms	Dabcyl-KTSAVLQSGFRKME-Edans; SARS-CoV 3CL Protease Substrate; Fluorogenic SARS-CoV 3CLpro Substrate; Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys(Methyl-EtOH)-Glu-Edans; SARS Coronavirus Main Protease Substrate; Mpro Fluorogenic Peptide Substrate; 3C-like Protease (3CLpro) Substrate; COVID-19 Protease Research Peptide
EINECS	Contact for details

Quality Control

Every batch of Dabcyl-Lys-Hcov-Sars Replicase Polyprotein 1Ab (3235-3246)-Glu-Edans is manufactured and analyzed under strict quality systems. We guarantee high purity (typically ≥95% by HPLC) and identity confirmation to ensure reliable and reproducible performance in sensitive assays. Certificates of Analysis (COA) with full chromatographic data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.