Description

(S,S)-(+)-6,6'-[(1,1'-Biphenyl-2,2'-Diyl)]Bis[4,8-Di-T-Butyl-1,2,10,11-Tetramethyl]Dibenzo[D,F][1,3,2]Dioxaphosphepinbisacetonitrileadduct,Min.95%(S,S)-Kelliphite is a high-purity, chiral phosphine-oxazoline ligand, widely recognized for its exceptional performance in asymmetric catalysis. This compound is critical for enabling highly enantioselective transformations, providing researchers and manufacturers with a reliable tool to produce single-enantiomer intermediates and active pharmaceutical ingredients (APIs). It is an indispensable reagent for synthetic organic chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to establish robust and efficient chiral synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for synthesizing chiral amino acids, alcohols, and amines.
• Pharmaceutical Intermediate Synthesis: Used in the key catalytic steps for manufacturing enantiomerically pure drug candidates and complex APIs, ensuring high optical purity.
• Agrochemical Production: Facilitates the synthesis of chiral active ingredients for herbicides, fungicides, and insecticides with improved efficacy and environmental profile.
• Asymmetric C-C Bond Formation: Employed in rhodium or palladium-catalyzed reactions such as allylic alkylation and hydroformylation to construct chiral carbon frameworks.
• Academic & Process R&D: A valuable tool for methodology development and scaling up novel asymmetric catalytic processes in research laboratories.
• Fine Chemical Manufacturing: Enables the production of high-value chiral flavors, fragrances, and specialty materials.

Basic Information

Item	Details
Product Name	(S,S)-(+)-6,6'-[(1,1'-Biphenyl-2,2'-Diyl)]Bis[4,8-Di-T-Butyl-1,2,10,11-Tetramethyl]Dibenzo[D,F][1,3,2]Dioxaphosphepinbisacetonitrileadduct,Min.95%(S,S)-Kelliphite
CAS No.	729572-33-2
Molecular Formula	C58H68N2O2P2
Molecular Weight	911.12 g/mol
Synonyms	(S,S)-Kelliphite; (S,S)-Kelliphite Ligand; (S,S)-6,6'-[(1,1'-Biphenyl-2,2'-diyl)]bis[4,8-di-tert-butyl-1,2,10,11-tetramethyldibenzo[d,f][1,3,2]dioxaphosphepin] bis(acetonitrile) adduct; (S,S)-BIPHEP-based PHOX Ligand; (S,S)-TetraMe-BITIANP; Chiral Phosphine-Oxazoline Ligand; Asymmetric Hydrogenation Ligand
EINECS	Contact for details

Quality Control

Our (S,S)-Kelliphite is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 95.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Water Content (KF)	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.