Description

2-(2-Fluorophenyl)Ethane-1-Sulfonyl Chloride is a specialized organosulfur building block of significant interest in advanced synthetic chemistry. Its core value lies in its dual functionality as a sulfonyl chloride and a fluorinated aromatic moiety, enabling precise molecular construction. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel sulfonamide derivatives and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing sulfonamide pharmacophores, particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the fluorophenylsulfonyl group can enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the preparation of specialty polymers with unique surface properties or chemical resistance.
• Chemical Biology & Proteomics: Acts as an electrophilic probe or labeling reagent for studying protein function and interactions due to its reactivity with nucleophilic amino acid residues.
• Ligand Synthesis for Catalysis: Employed in the preparation of sophisticated ligands for transition metal catalysis, where the sulfonamide group can act as a coordinating moiety.

Basic Information

Product Name	2-(2-Fluorophenyl)Ethane-1-Sulfonyl Chloride
CAS No.	728919-67-3
Molecular Formula	C8H8ClFO2S
Molecular Weight	222.66 g/mol
Synonyms	2-(2-Fluorophenyl)ethanesulfonyl chloride; 1-(2-Fluorophenyl)-2-chlorosulfonylethane; 2-Fluorophenethylsulfonyl chloride; (2-Fluorophenyl)ethylsulfonyl chloride; 2-(2-Fluorophenyl)ethylsulfonyl chloride; 728919-67-3; 2-(2-Fluorophenyl)ethane-1-sulfonyl chloride; 2-(2-Fluorobenzyl)ethanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-(2-Fluorophenyl)Ethane-1-Sulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent hydrolysis and degradation. Keep away from moisture, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.