Description

L-Threonine, n-(4-Ethynylbenzoyl)-, Methyl Ester CAS NO 728878-24-8 is a specialized, high-purity synthetic amino acid derivative designed for advanced research and development. This compound is a critical building block in medicinal chemistry, valued for its unique molecular architecture that incorporates both a protected amino acid backbone and an ethynylbenzoyl moiety. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the synthesis of novel bioactive molecules, including peptide mimetics and targeted covalent inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for targeted covalent therapies.
• Peptidomimetic Research: Used to construct and modify peptide-like structures to enhance stability, bioavailability, and target affinity.
• Chemical Biology Probes: Serves as a versatile scaffold for developing activity-based probes to study enzyme function and protein interactions.
• Bioconjugation: The ethynyl group enables efficient, site-specific conjugation via click chemistry for antibody-drug conjugates (ADCs) or diagnostic agents.
• Academic & Institutional R&D: Employed in university and research institute laboratories for exploratory synthetic and medicinal chemistry projects.
• Process Development: Used by process chemists to scale up and optimize synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	L-Threonine, n-(4-Ethynylbenzoyl)-, Methyl Ester
CAS No.	728878-24-8
Molecular Formula	C15H15NO4
Molecular Weight	273.28 g/mol
Synonyms	Methyl N-(4-ethynylbenzoyl)-L-threoninate; (2S,3R)-Methyl 2-[(4-ethynylbenzoyl)amino]-3-hydroxybutanoate; L-Threonine, N-(4-ethynylbenzoyl)-, methyl ester; Methyl (2S,3R)-2-[(4-ethynylbenzamido)]-3-hydroxybutanoate; 4-Ethynyl-N-[(2S,3R)-1-methoxy-3-methyl-1-oxobutan-2-yl]benzamide; N-(4-Ethynylbenzoyl)threonine methyl ester
EINECS	Contact for details

Quality Control

Our L-Threonine, n-(4-Ethynylbenzoyl)-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity analysis to ensure identity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP-grade production for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.