Description

(Val2)-Amyloid β-Protein (1-6) CAS NO 727727-66-4 is a synthetic peptide fragment derived from the N-terminal region of the amyloid-β protein, a key molecule in Alzheimer's disease research. This high-purity, sequence-specific peptide is critical for advancing scientific understanding of protein aggregation mechanisms and developing targeted diagnostic or therapeutic agents. It is an essential research-grade biochemical for pharmaceutical R&D, academic institutions, and biotechnology companies focused on neurodegenerative diseases and peptide chemistry.

Application

• Biomedical Research: Fundamental studies on the structure, aggregation kinetics, and toxicity of amyloid-β peptides related to Alzheimer's disease pathology.
• Drug Discovery & Screening: Used as a reference standard or target molecule in high-throughput assays to identify and validate potential inhibitors of amyloid aggregation.
• Antibody Development & Epitope Mapping: Serves as a specific antigen for the production and characterization of antibodies targeting the N-terminal region of amyloid-β.
• Diagnostic Reagent Production: A key component in the development and calibration of immunoassays (e.g., ELISA) and other diagnostic kits for detecting amyloid-β variants.
• Peptide Chemistry & Conjugation: Acts as a building block for synthesizing larger peptide constructs or for conjugation with labels (e.g., fluorescent dyes, biotin) for advanced imaging and detection studies.
• Academic & Teaching Laboratories: Provides a well-defined peptide for educational purposes and method development in biochemistry and molecular biology courses.

Basic Information

Product Name	(Val2)-Amyloid β-Protein (1-6)
CAS No.	727727-66-4
Molecular Formula	C31H51N9O9
Molecular Weight	693.8 g/mol
Synonyms	DAEFVH; Amyloid β-Protein (1-6) (human); Aβ (1-6); Amyloid β-Peptide (1-6); β-Amyloid (1-6); Asp-Ala-Glu-Phe-Val-His; H-Asp-Ala-Glu-Phe-Val-His-OH; DAEFRH (with Arg at position 5, common variant); Valine-2 substituted Aβ(1-6)
EINECS	Contact for details

Quality Control

Every batch of our (Val2)-Amyloid β-Protein (1-6) is manufactured and analyzed under strict quality management systems. We guarantee high purity and batch-to-batch consistency through comprehensive analytical techniques including HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and peptide content. Our quality commitment supports research requiring reliable and reproducible biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area percent at 214 nm)
Peptide Content	≥ 70% (by amino acid analysis)
Solubility	Soluble in water or aqueous buffers
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.