Description

Fmoc-S-Trityl-α-Me-L-Cysteine is a sophisticated, orthogonally protected non-proteinogenic amino acid derivative, specifically engineered for advanced peptide synthesis. This compound is critical for introducing the unique steric and chemical properties of α-methyl cysteine into peptide chains, enabling the creation of novel structures with enhanced stability and biological activity. It is an essential building block for pharmaceutical researchers and peptide chemists focused on developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of α-methyl-L-cysteine into peptide sequences, particularly in Fmoc-based strategies.
• Pharmaceutical Research & Development: Used in the synthesis of constrained peptide analogs and peptidomimetics for drug discovery programs targeting various diseases.
• Bioconjugation and Protein Engineering: Serves as a precursor for introducing thiol-reactive handles or stable, methylated cysteine linkages into proteins and other biomolecules.
• Chemical Biology Probes: Enables the creation of labeled or modified peptides used to study protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Material Science: Potential use in synthesizing specialized peptide-based polymers or surface coatings where enhanced chemical resistance is required.

Basic Information

Product Name	Fmoc-S-Trityl-α-Me-L-Cysteine
CAS No.	725728-43-8
Molecular Formula	C38H33NO4S
Molecular Weight	599.74 g/mol
Synonyms	Fmoc-α-Me-Cys(Tr)-OH; N-(9-Fluorenylmethoxycarbonyl)-S-trityl-α-methyl-L-cysteine; Fmoc-S-Trt-α-Me-L-Cys-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-3-(tritylsulfanyl)propanoic acid; Fmoc-Cys(α-Me, Trt)-OH; Nα-Fmoc-S-trityl-α-methyl-L-cysteine; Fmoc-α-methylcysteine(S-trityl); Fmoc-L-α-methylcysteine(Strt)
EINECS	Contact for details

Quality Control

Our Fmoc-S-Trityl-α-Me-L-Cysteine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and our quality systems support the needs of customers operating under cGMP guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.