Description

(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-2-Methyl-3-Tritylsulfanylpropanoic Acid is a sophisticated, non-natural amino acid derivative designed for advanced peptide synthesis and chemical research. This compound matters for its role as a key building block in the solid-phase synthesis of complex peptides, particularly where the introduction of a protected thiol side chain is required. Pharmaceutical researchers and fine chemical manufacturers need this high-purity intermediate to develop novel therapeutic peptides, peptidomimetics, and for applications in bioconjugation and material science.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical Fmoc-protected amino acid building block for the controlled incorporation of a protected cysteine analog into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of novel peptide-based drug candidates, including those targeting protein-protein interactions.
• Peptidomimetic Design: Enables the creation of stabilized peptide analogs with enhanced metabolic stability and bioavailability.
• Bioconjugation Chemistry: The trityl-protected thiol group serves as a handle for site-specific labeling or attachment to surfaces, polymers, or other biomolecules.
• Chemical Biology Probes: Synthesis of specialized amino acids for probing enzyme mechanisms or studying protein structure and function.
• Material Science: Potential use in creating peptide-based nanomaterials or self-assembling systems where thiol functionality is key.

Basic Information

Product Name	(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-2-Methyl-3-Tritylsulfanylpropanoic Acid
CAS No.	725728-37-0
Molecular Formula	C41H35NO4S
Molecular Weight	637.79 g/mol
Synonyms	Fmoc-Cys(Trityl)-OH (methylated β-carbon analog); Fmoc-Cys(Trt)-OH (β-methyl derivative); (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-3-(triphenylmethylthio)propanoic acid; Fmoc-β-methyl-Cys(Trt)-OH; N-α-Fmoc-S-trityl-β-methyl-L-cysteine; Fmoc-L-β-methyl-Cys(Trt)-OH; Fmoc-β-Me-Cys(Trt)-OH; N-Fmoc-S-trityl-β-methylcysteine
EINECS	Contact for details

Quality Control

Our production of this advanced amino acid derivative adheres to stringent GMP-like guidelines to ensure batch-to-batch consistency for sensitive research and development applications. Every lot undergoes comprehensive analysis via HPLC, NMR, and MS to confirm identity, chiral purity, and chemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity (typically >98% by HPLC), specific rotation, and residual solvent levels.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]20/D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.