Description

Cyclopropanecarboxylic Acid, 1-Amino-2,2-Difluoro-, (1S)- (9Ci) is a high-value, chiral fluorinated cyclopropane derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) for the synthesis of novel active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors, where its unique stereochemistry and fluorine substitution enable the development of compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the difluorocyclopropane motif can improve efficacy and environmental profile.
• Chemical Biology & Medicinal Chemistry: Employed as a probe or scaffold in structure-activity relationship (SAR) studies to investigate protein-ligand interactions.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the optimization and commercial-scale production of fine chemicals.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists exploring new methodologies involving fluorinated and strained ring systems.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-Amino-2,2-Difluoro-, (1S)- (9Ci)
CAS No.	724700-75-8
Molecular Formula	C4H5F2NO2
Molecular Weight	137.09 g/mol
Synonyms	(1S)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid; (1S)-1-Amino-2,2-difluorocyclopropanecarboxylic acid; L-1-Amino-2,2-difluorocyclopropanecarboxylic acid; (S)-1-Amino-2,2-difluorocyclopropanecarboxylic acid; 1-Amino-2,2-difluorocyclopropanecarboxylic acid (S enantiomer); Difluorocyclopropane amino acid; ADFC; CAS 724700-75-8
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 1-Amino-2,2-Difluoro-, (1S)- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.