Description

(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Methoxyimino)Acetamido)-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Hydrochloride is a high-purity pharmaceutical intermediate, specifically a key cephalosporin nucleus derivative. This compound is of critical importance for the synthesis of advanced third and fourth-generation cephalosporin antibiotics, offering a reliable building block for active pharmaceutical ingredient (API) manufacturing. It is primarily needed by pharmaceutical companies, research institutions, and fine chemical suppliers engaged in the development and production of potent, broad-spectrum antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A crucial intermediate in the manufacturing of advanced cephalosporin antibiotics like cefotaxime and other methoxyimino-substituted derivatives.
• Pharmaceutical Research & Development: Serves as a key starting material or reference standard in the R&D of new antibacterial compounds and novel drug delivery systems.
• Fine Chemical Production: Used in the multi-step synthesis of complex, high-value molecules within the fine chemical and custom synthesis sector.
• Reference Standard: Employed as a certified reference material (CRM) in analytical laboratories for quality control and method validation of cephalosporin-based drugs.
• Process Chemistry: Utilized in process optimization and scale-up studies for more efficient and cost-effective antibiotic production.

Basic Information

Item	Details
Product Name	(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Methoxyimino)Acetamido)-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Hydrochloride
CAS No.	724438-16-8
Molecular Formula	C15H17N5O5S2 • HCl
Molecular Weight	464.92 g/mol
Synonyms	7-ACA Derivative (Methoxyimino); 7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrochloride; Cephalosporanic Acid Derivative; Cefotaxime Intermediate; (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrochloride; 7-ATMA Hydrochloride; 7-ACA Methoxyimino Thiazole Intermediate HCl Salt
EINECS	Contact for details

Quality Control

Our (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Methoxyimino)Acetamido)-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your GMP and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Specific range available on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.