Description

(R)-2-((tert-Butoxycarbonyl)Amino)-4-(Dimethylamino)-4-Oxobutanoic Acid is a high-purity, non-natural amino acid derivative featuring both Boc-protected amine and dimethylamide functionalities. This compound serves as a critical chiral building block and advanced intermediate in the synthesis of complex, biologically active molecules. It is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly for constructing peptide mimetics, protease inhibitors, and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in oncology and antiviral research.
• Peptidomimetic Synthesis: Used to incorporate modified amino acid residues into peptide chains to enhance stability, bioavailability, and target specificity.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology & Drug Discovery: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthetic routes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and clinical trial materials.

Basic Information

Product Name	(R)-2-((tert-Butoxycarbonyl)Amino)-4-(Dimethylamino)-4-Oxobutanoic Acid
CAS No.	721928-03-6
Molecular Formula	C11H20N2O5
Molecular Weight	260.29 g/mol
Synonyms	Boc-D-Asp(DMA)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-4-(dimethylamino)-4-oxobutanoic acid; Boc-Asp(Dimethylamide)-OH, D-; D-Boc-Asp(DMA)-OH; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-4-(dimethylamino)-4-oxobutanoic acid; Boc-D-Aspartic acid dimethylamide; N-Boc-D-Aspartic acid dimethylamide; Nα-Boc-D-aspartic acid dimethylamide
EINECS	Contact for details

Quality Control

Our production of (R)-2-((tert-Butoxycarbonyl)Amino)-4-(Dimethylamino)-4-Oxobutanoic Acid adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.