Description

(R)-2-((tert-Butoxycarbonyl)Amino)-5-(Dimethylamino)-5-Oxopentanoic Acid is a high-purity, non-natural amino acid derivative featuring both Boc-protected amine and dimethylamide functionalities. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel therapeutic agents, including protease inhibitors and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and enzyme-targeted therapies.
• Peptide Synthesis: Serves as a specialized, protected amino acid residue in solid-phase and solution-phase peptide synthesis to construct complex peptide sequences with specific side-chain modifications.
• Bioconjugation & Linker Chemistry: Used in the design and synthesis of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted delivery platforms.
• Chemical Biology Research: Employed as a tool compound or building block for probing enzyme mechanisms and studying protein-protein interactions.
• Fine Chemical Synthesis: Acts as a versatile intermediate for the preparation of more complex molecules in agrochemical and advanced material research.

Basic Information

Product Name	(R)-2-((tert-Butoxycarbonyl)Amino)-5-(Dimethylamino)-5-Oxopentanoic Acid
CAS No.	721927-50-0
Molecular Formula	C12H22N2O5
Molecular Weight	274.32 g/mol
Synonyms	Boc-D-Glu(NMe2)-OH; (R)-5-(Dimethylamino)-2-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-5-(dimethylamino)-5-oxopentanoic acid; Boc-D-glutamic acid 5-dimethylamide; N-Boc-D-glutamic acid dimethylamide; D-Glutamic acid, N-(1,1-dimethylethoxy)carbonyl]-, 5-(dimethylamide); N-(tert-Butoxycarbonyl)-D-glutamic acid dimethylamide
EINECS	Contact for details

Quality Control

Our (R)-2-((tert-Butoxycarbonyl)Amino)-5-(Dimethylamino)-5-Oxopentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and cGMP-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.