Description

[13C6]-Irinotecan is a stable isotope-labeled analog of the potent topoisomerase I inhibitor, irinotecan, where six carbon atoms are replaced with the non-radioactive carbon-13 isotope. This compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on oncology drug development and clinical research.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of irinotecan and its metabolites in biological matrices (plasma, serum, tissue).
• Enables accurate pharmacokinetic (PK) and pharmacodynamic (PD) studies during clinical trials and non-clinical research.
• Facilitates drug metabolism and disposition (DMPK) studies to understand the metabolic pathways and clearance of irinotecan.
• Supports bioequivalence and bioavailability studies for generic drug development.
• Critical for therapeutic drug monitoring (TDM) assays to optimize patient dosing regimens.
• Employed in high-throughput screening and method development in analytical laboratories.

Basic Information

Product Name	[13C6]-Irinotecan
CAS No.	718613-65-1
Molecular Formula	C33H3813C6N4O6
Molecular Weight	~ 659.71 g/mol (for 13C6 labeled form)
Synonyms	(+)-(4S)-4,11-Diethyl-4-hydroxy-9-[(4-piperidinopiperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-13C6; Irinotecan-13C6; CPT-11-13C6; Camptosar-13C6 (labeled); 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin-13C6; Isotopically Labeled Irinotecan Internal Standard
EINECS	Contact for details

Quality Control

Every batch of [13C6]-Irinotecan is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure high chemical purity, isotopic enrichment, and structural identity, meeting the exacting standards required for analytical internal standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for purity (HPLC), isotopic purity (MS), and identification (NMR/IR). Our quality commitment supports compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C (on labeled positions)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.