Description

7-Ethyl-10-Hydroxy Camptothecin-D5 is a deuterated analog of the potent topoisomerase I inhibitor, SN-38. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in quantitative bioanalytical studies, serving as an essential internal standard. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in the development and pharmacokinetic analysis of camptothecin-derived anticancer therapeutics, such as irinotecan.

Application

• Primary use as an Internal Standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of SN-38 and related metabolites in biological matrices.
• Supporting Pharmacokinetic (PK) and Bioanalytical Studies during the preclinical and clinical development of irinotecan and other camptothecin analogs.
• Enabling Drug Metabolism and Pharmacokinetics (DMPK) research to understand absorption, distribution, metabolism, and excretion profiles.
• Facilitating Biomarker Analysis in oncology research for therapeutic drug monitoring and efficacy studies.
• Use in Stable Isotope Dilution Assays to achieve high analytical precision and compensate for matrix effects and instrument variability.

Basic Information

Product Name	7-Ethyl-10-Hydroxy Camptothecin-D5
CAS No.	718612-51-2
Molecular Formula	C22H14D5N2O5
Molecular Weight	~393.4 g/mol
Synonyms	SN-38-d5; 7-Ethyl-10-hydroxycamptothecin-d5; 10-Hydroxy-7-ethylcamptothecin-d5; (S)-10-Hydroxy-7-ethylcamptothecin-d5; 7-Ethyl-10-hydroxy-20(S)-camptothecin-d5; Deuterated SN-38; SN38-d5; Irinotecan Active Metabolite-d5
EINECS	Contact for details

Quality Control

This high-purity reference material is manufactured under cGMP-like conditions to ensure batch-to-batch consistency and traceability. Each lot undergoes comprehensive analytical characterization, including HPLC for chemical purity and MS/NMR for structural confirmation and isotopic enrichment verification. A detailed Certificate of Analysis (COA) is provided, documenting purity, deuterium content, and all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.