Description

S-n-Methyl-n-[(1S)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine is a sophisticated chiral organophosphorus compound, specifically a P-stereogenic phosphine-amine hybrid ligand. This compound matters for its exceptional ability to induce high enantioselectivity in asymmetric catalytic reactions, a critical factor for producing single-enantiomer pharmaceuticals and fine chemicals. It is primarily needed by research institutions and industrial chemists working in advanced asymmetric synthesis, particularly for hydrogenation and cross-coupling reactions where precise stereochemical control is paramount.

Application

• As a chiral ligand in asymmetric transition metal catalysis, including rhodium- and iridium-catalyzed hydrogenations.
• For the synthesis of enantiomerically pure pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• In academic and industrial R&D for developing novel asymmetric synthetic methodologies.
• As a key component in catalyst systems for C-C and C-X bond-forming reactions requiring high stereoselectivity.
• For the preparation of specialty fine chemicals and agrochemicals with defined chirality.
• In material science research for creating chiral molecular frameworks and polymers.

Basic Information

Product Name	S-n-Methyl-n-[(1S)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine
CAS No.	712352-04-0
Molecular Formula	C29H26NOP
Molecular Weight	435.50 g/mol
Synonyms	(S)-Methyl((S)-1-phenylethyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (S,S)-Methyl(1-phenylethyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (S,S)-Me-PENAPHOS; Me-PENAPHOS; (S,S)-MePENAPHOS; P-((S)-1-Phenylethyl)-P-methyl-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; Chiral phosphine-amine ligand 712352-04-0.
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to stringent quality protocols. Every batch undergoes comprehensive analysis, including chiral HPLC to confirm enantiomeric purity and NMR spectroscopy for structural verification. We ensure compliance with relevant research and development standards, and a detailed Certificate of Analysis (COA) documenting purity, chiral assay, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.