Description

3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in the strategic combination of a reactive amine group and a protected boronic acid (pinacol boronate ester), enabling efficient cross-coupling reactions like Suzuki-Miyaura. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and material science who require precise molecular construction.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety facilitates efficient carbon-carbon bond formation with aryl/heteroaryl halides, crucial for creating complex biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Building block for organic electronic materials, such as fluorinated polymers and small molecules for OLEDs or semiconductors.
• Chemical Biology & Proteomics: Utilized in the synthesis of probes and linkers for studying biological systems and protein interactions.

Basic Information

Product Name	3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine
CAS No.	710348-95-1
Molecular Formula	C12H17BFNO2
Molecular Weight	237.08 g/mol
Synonyms	3-Amino-5-fluorophenylboronic acid pinacol ester; 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; (3-Amino-5-fluorophenyl)boronic acid pinacol ester; 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 3-Fluoro-5-(pinacolboron)aniline; 710348-95-1; 3-Fluoro-5-(pinacolato)borylaniline
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Comprehensive Certificates of Analysis (COA) with detailed HPLC/GC and NMR data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.