Description

3-Amino-3-Fluoromethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected pyrrolidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both a fluoromethyl group and a protected amine, makes it indispensable for introducing fluorinated motifs into complex molecular architectures. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where its scaffold can impart improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Research: Used in the development of novel, fluorinated pesticides and herbicides to enhance their activity and environmental profile.
• Fluorine Chemistry: Serves as a versatile precursor for introducing the -CH2F moiety into complex molecules via further functionalization of the amine group.
• Peptidomimetics & PROTACs: The pyrrolidine core is a valuable scaffold for constructing conformationally constrained peptides and designing Proteolysis Targeting Chimeras (PROTACs).
• Ligand & Catalyst Development: Utilized in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes for studying biological mechanisms and enzyme interactions.

Basic Information

Product Name	3-Amino-3-Fluoromethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	708274-54-8
Molecular Formula	C10H19FN2O2
Molecular Weight	218.27 g/mol
Synonyms	1-Boc-3-Amino-3-Fluoromethylpyrrolidine; tert-Butyl 3-Amino-3-(fluoromethyl)pyrrolidine-1-carboxylate; 3-(Fluoromethyl)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester; 3-Amino-3-(fluoromethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; 1-N-Boc-3-Amino-3-Fluoromethylpyrrolidine; 3-Fluoromethyl-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester; (3R/S)-3-Amino-3-fluoromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-Amino-3-Fluoromethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation via NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is supplied with each batch, and custom synthesis to meet specific purity or enantiomeric excess requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.