Description

C5A Anaphylatoxin (37-53) (Human) is a synthetic peptide fragment corresponding to residues 37-53 of the human C5a anaphylatoxin protein. This compound is a critical research tool for studying the complement system, inflammation, and immune response pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on immunology, drug discovery, and the development of therapeutic agents targeting inflammatory diseases.

Application

• Immunological Research: Used as a reference standard and active agent in studies of the complement cascade, C5a receptor (C5aR) activation, and neutrophil chemotaxis.
• Drug Discovery & Screening: Serves as a key ligand in high-throughput screening (HTS) assays to identify and characterize potential C5aR antagonists and anti-inflammatory compounds.
• In Vitro Bioassays: Employed in cell-based assays to model inflammatory responses, measure calcium flux, and evaluate cytokine release.
• Biomarker Studies: Used in the development and validation of diagnostic methods for detecting complement activation in disease states.
• Peptide Chemistry & Conjugation: Acts as a starting material or target sequence for the synthesis of modified peptides, fluorescent probes, or bioconjugates for advanced research applications.

Basic Information

Product Name	C5A Anaphylatoxin (37-53) (Human)
CAS No.	706808-05-1
Molecular Formula	C84H137N25O27S
Molecular Weight	1913.2 g/mol
Synonyms	C5a (37-53), human; Complement C5a Anaphylatoxin (37-53); H-Tyr-Ser-Lys-Lys-Pro-Pro-Ser-Cys-Arg-Ala-Ala-His-Pro-Ala-Arg-Ser-Cys-OH (Disulfide bridge: Cys8-Cys17); C5a Peptide Fragment (37-53); Human Complement Component 5a (37-53); C5a Receptor Ligand (37-53); Anaphylatoxin C5a (37-53) human; C5a(37-53)
EINECS	Contact for details

Quality Control

Our C5A Anaphylatoxin (37-53) (Human) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.