Description

Boc-(S)-α-(3-Chlorobenzyl)-Proline is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a proline derivative with a protected amine and a substituted benzyl side chain.
• Chemical Biology Research: Employed in the synthesis of custom peptides and peptidomimetics for studying protein-protein interactions and biological pathways.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by providing a versatile scaffold for the introduction of diverse functional groups.
• Catalyst and Ligand Development: Can be utilized in the synthesis of chiral catalysts or ligands for asymmetric synthesis applications.

Basic Information

Product Name	Boc-(S)-α-(3-Chlorobenzyl)-Proline
CAS No.	706806-69-1
Molecular Formula	C₁₈H₂₄ClNO₄
Molecular Weight	353.84 g/mol
Synonyms	(S)-1-[(tert-Butoxycarbonyl)]-2-[(3-chlorophenyl)methyl]pyrrolidine-2-carboxylic acid; (S)-1-Boc-2-(3-chlorobenzyl)proline; (S)-1-(tert-Butoxycarbonyl)-2-(3-chlorobenzyl)proline; tert-Butyl (2S)-2-(3-chlorobenzyl)-1,2-pyrrolidinedicarboxylate; Boc-3-Cl-Bzl-Pro-OH; (S)-α-(3-Chlorobenzyl)-N-Boc-proline; Boc-(S)-3-Chlorobenzylproline
EINECS	Contact for details

Quality Control

Our Boc-(S)-α-(3-Chlorobenzyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.