Description

Boc-(S)-α-(4-Fluorobenzyl)-Proline is a high-purity, non-natural amino acid derivative featuring a Boc-protected proline core and a chiral 4-fluorobenzyl side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of complex, biologically active molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of peptide-based therapeutics and small molecule drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetic Research: Used to introduce constrained proline analogs and fluorinated aromatic motifs into peptide backbones to enhance metabolic stability and binding affinity.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative for the automated synthesis of custom peptides for screening and development.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and labeled compounds for target identification and validation studies.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	Boc-(S)-α-(4-Fluorobenzyl)-Proline
CAS No.	706806-65-7
Molecular Formula	C₁₇H₂₂FNO₄
Molecular Weight	323.36 g/mol
Synonyms	(S)-1-[(tert-Butoxycarbonyl)]-2-[(4-fluorophenyl)methyl]pyrrolidine-2-carboxylic acid; (S)-1-Boc-2-(4-fluorobenzyl)proline; Boc-(S)-2-(4-Fluorobenzyl)proline; (S)-1-(tert-Butoxycarbonyl)-2-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid; tert-Butyl (2S)-2-(4-fluorobenzyl)-2-(carboxy)pyrrolidine-1-carboxylate; (S)-1-Boc-2-(4-Fluorobenzyl)pyrrolidine-2-carboxylic Acid; (S)-N-Boc-2-(4-Fluorobenzyl)proline
EINECS	Contact for details

Quality Control

Our Boc-(S)-α-(4-Fluorobenzyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing specifications such as chiral purity, chemical purity (by HPLC), and residual solvent levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.