Description

A-Conotoxin Pnia CAS NO 705300-84-1 is a highly specific and potent peptide neurotoxin derived from the venom of cone snails. This compound is of significant value in neuroscience research for its selective antagonism of nicotinic acetylcholine receptors (nAChRs). It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neurological studies, ion channel research, and the development of novel therapeutic agents for pain management and neurological disorders.

Application

• Neuroscience Research: As a selective pharmacological tool for studying the function and distribution of specific subtypes of nicotinic acetylcholine receptors (nAChRs).
• Ion Channel Characterization: Used in electrophysiology and binding assays to characterize and differentiate between various neuronal nAChR subtypes.
• Drug Discovery & Development: Serves as a lead compound or molecular template for developing new analgesics and neuroprotective agents targeting the cholinergic system.
• Biochemical Studies: Employed in the investigation of synaptic transmission, receptor-ligand interactions, and signal transduction pathways.
• Academic & Pharmaceutical R&D: A critical reagent in basic research and high-throughput screening programs aimed at identifying new treatments for chronic pain, addiction, and neurodegenerative diseases.

Basic Information

Product Name	A-Conotoxin Pnia
CAS No.	705300-84-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	α-Conotoxin PnIA; α-Conotoxin PnIA; Conotoxin PnIA; PnIA; α-PnIA; PnIA Peptide; Nicotinic Acetylcholine Receptor Antagonist PnIA
EINECS	Contact for details

Quality Control

Our A-Conotoxin Pnia is produced and controlled under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, mass spectrometry for identity confirmation, and potency evaluation via bioassay. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solubility	Soluble in aqueous buffers
Biological Activity (IC50)	Specification available upon request

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.