Description

Cetirizine Descarboxymethyl R-Isomer is a key chiral intermediate in the synthesis of advanced pharmaceutical compounds. This high-purity isomer is critical for ensuring the enantiomeric purity and efficacy of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the production of enantiomerically pure antihistamines and related therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of enantiomerically pure Cetirizine and its derivatives.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new chiral drug candidates.
• Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale manufacturing of chiral pharmaceuticals.
• Asymmetric Synthesis Research: A valuable compound for academic and industrial research in stereoselective synthesis methodologies.

Basic Information

Product Name	Cetirizine Descarboxymethyl R-Isomer
CAS No.	705289-61-8
Molecular Formula	C19H22ClN3O2
Molecular Weight	359.85 g/mol
Synonyms	(R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol; (R)-Cetirizine Descarboxymethyl; R-Cetirizine Descarboxymethyl; Levocetirizine Descarboxymethyl Intermediate; (R)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol; ZYRTEC Descarboxymethyl R-Isomer
EINECS	Contact for details

Quality Control

Our Cetirizine Descarboxymethyl R-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) documenting identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.