Description

(E)-Methyl 3-(3,5-Difluorophenyl)Acrylate is a high-purity fluorinated acrylate ester building block, essential for advanced organic synthesis. Its core value lies in the strategic incorporation of difluorophenyl and acrylate functionalities, enabling precise molecular design for performance materials and active pharmaceutical ingredients. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, particularly kinase inhibitors and other targeted therapies where the difluorophenyl moiety is critical.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging its structural motif for enhanced biological activity and environmental stability.
• Material Science Monomer: Serves as a precursor for specialty polymers and coatings, where the fluorine atoms can impart desirable properties like chemical resistance, low surface energy, and thermal stability.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic display and lighting applications.
• Cross-coupling Reactions: Acts as a competent substrate in Heck, Suzuki, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Chemical Biology Probes: Useful for introducing photoaffinity labels or fluorinated tags into molecules for mechanistic studies and diagnostic applications.

Basic Information

Product Name	(E)-Methyl 3-(3,5-Difluorophenyl)Acrylate
CAS No.	705250-75-5
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	Methyl (E)-3-(3,5-Difluorophenyl)acrylate; Methyl 3-(3,5-Difluorophenyl)-2-propenoate; (E)-3-(3,5-Difluorophenyl)-2-propenoic Acid Methyl Ester; trans-Methyl 3-(3,5-Difluorocinnamate); 3,5-Difluorocinnamic Acid Methyl Ester; (E)-Methyl 3,5-Difluorocinnamate; Methyl trans-3,5-Difluorocinnamate; 705250-75-5
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(3,5-Difluorophenyl)Acrylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0% (Area %)
Isomeric Purity ((E)-isomer)	≥ 99.0% (by HPLC)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.