Description

4,7-Methanoisobenzofuran-1,3-Dione,3A,7A-Difluoro-3A,4,7,7A-Tetrahydro-(9Ci) is a specialized fluorinated bicyclic anhydride derivative, serving as a critical high-value intermediate in advanced organic synthesis. Its unique molecular architecture, featuring a strained methano-bridge and fluorine substituents, makes it a versatile building block for constructing complex molecules with tailored electronic and steric properties. This compound is essential for R&D and production in industries focused on pharmaceuticals, agrochemicals, and advanced material science, where precise fluorination is required to modulate bioactivity, stability, and material characteristics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Building block for developing next-generation fluorinated pesticides and herbicides, where fluorine atoms enhance lipophilicity, metabolic stability, and target binding.
• Advanced Material Science: Monomer or cross-linking agent for synthesizing specialty polymers, resins, and coatings with enhanced thermal stability, chemical resistance, and unique surface properties.
• Ligand and Catalyst Development: Used to create novel fluorinated ligands for asymmetric catalysis and organometallic complexes, improving reaction selectivity and efficiency.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the properties of fluoroorganic compounds.
• Electronic Chemicals: Potential intermediate in the production of fluorinated compounds for electronic applications, such as dielectric materials or photoacid generators (PAGs) for photoresists.

Basic Information

Product Name	4,7-Methanoisobenzofuran-1,3-Dione,3A,7A-Difluoro-3A,4,7,7A-Tetrahydro-(9Ci)
CAS No.	701294-38-4
Molecular Formula	C9H6F2O3
Molecular Weight	200.14 g/mol
Synonyms	3a,7a-Difluoro-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1,3-dione; 3a,7a-Difluoro-3a,4,7,7a-tetrahydro-4,7-epoxyisobenzofuran-1,3-dione; 3a,7a-Difluorotetrahydro-4,7-methanoisobenzofuran-1,3-dione; Difluorinated bicyclic anhydride; 3a,7a-Difluorohexahydro-4,7-epoxyisobenzofuran-1,3-dione; 701294-38-4 (CAS Name); Fluorinated nadic anhydride derivative
EINECS	Contact for details

Quality Control

Our production of 4,7-Methanoisobenzofuran-1,3-Dione,3A,7A-Difluoro-3A,4,7,7A-Tetrahydro-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the anhydride functionality. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.