Description

(1R,2R)-1,2-Bis((S)-4-Isopropyl-4,5-Dihydrooxazol-2-Yl)Cyclohexane CAS NO 700381-43-7 is a high-purity, chiral bis(oxazoline) ligand, a critical class of compounds in asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in catalytic reactions, enabling the production of single-enantiomer intermediates essential for advanced pharmaceuticals and fine chemicals. This product is specifically engineered for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance ligands for metal-catalyzed transformations.

Application

• Asymmetric Catalysis: As a privileged ligand for copper, palladium, and other transition metals in enantioselective C–H activation, cyclopropanation, and Diels-Alder reactions.
• Pharmaceutical Intermediate Synthesis: For the production of chiral active pharmaceutical ingredients (APIs) and key synthetic building blocks with high optical purity.
• Agrochemical Research: In the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Methodology Development: A versatile tool for academic and industrial research in discovering new asymmetric synthetic pathways.
• Fine Chemical Manufacturing: Used in the scaled-up synthesis of specialty flavors, fragrances, and advanced materials requiring specific chirality.

Basic Information

Product Name	(1R,2R)-1,2-Bis((S)-4-Isopropyl-4,5-Dihydrooxazol-2-Yl)Cyclohexane
CAS No.	700381-43-7
Molecular Formula	C20H32N2O2
Molecular Weight	332.48 g/mol
Synonyms	(1R,2R)-1,2-Bis[(4S)-4-(1-Methylethyl)-4,5-dihydro-2-oxazolyl]cyclohexane; (R,R)-Cyclohexane-1,2-diylbis[(4S)-4-isopropyl-4,5-dihydrooxazole]; (R,R)-Cyclohexyl-BOX; (R,R)-Cyclohexane-bis(4S-isopropyloxazoline); Chiral Bis(oxazoline) Ligand; (R,R)-CyHex-BOX; (1R,2R)-(-)-1,2-Bis[(4S)-4-isopropyl-2-oxazolin-2-yl]cyclohexane; (R,R)-1,2-Bis[(S)-4-isopropyl-2-oxazolinyl]cyclohexane
EINECS	Contact for details

Quality Control

Our (1R,2R)-1,2-Bis((S)-4-Isopropyl-4,5-Dihydrooxazol-2-Yl)Cyclohexane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding catalytic applications. Certificates of Analysis (COA) with full characterization data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to maintain optimal purity and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.