Description

Conotoxin Gia CAS NO 79982-99-3 is a highly specific and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is a critical research tool for studying and characterizing N-type voltage-gated calcium channels (Cav2.2) in neuronal signaling pathways. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in neuroscience, pain research, and ion channel drug discovery.

Application

• Neuroscience Research: A selective pharmacological blocker for the detailed study of N-type calcium channel function and distribution in the central and peripheral nervous systems.
• Pain Pathway Analysis: Used in experimental models to investigate the role of Cav2.2 channels in nociception and to validate targets for novel analgesic development.
• Ion Channel Profiling: Essential for electrophysiology assays (e.g., patch-clamp) to characterize channel subtypes and screen for potential modulators or inhibitors.
• Pharmacological Tool Compound: Serves as a reference standard in high-throughput screening (HTS) campaigns for neurological and neuropathic pain drug discovery programs.
• Biochemical Studies: Employed in binding assays and structural biology to understand toxin-channel interactions at the molecular level.
• Academic & Institutional Research: A key reagent for foundational research in cellular physiology, synaptic transmission, and neuropharmacology.

Basic Information

Product Name	Conotoxin Gia
CAS No.	79982-99-3
Molecular Formula	C98H150N30O29S6
Molecular Weight	~2299.8 g/mol
Synonyms	ω-Conotoxin GVIA; ω-Conotoxin GVIa; ω-Conotoxin GVIA; Conotoxin GVIA; CGVIA; SNX-124; Calcium channel blocker ω-conotoxin GVIA; Ctx GVIA; [Cys8,15,19,26, Arg17, Leu24]conotoxin GVIA
EINECS	Contact for details

Quality Control

Our Conotoxin Gia is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and bioactivity. We adhere to GMP-grade standards for research biochemicals, with quality systems designed to meet the exacting requirements of pharmaceutical R&D and advanced academic research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (typically low nM range vs. N-type Ca2+ channels)
Water Content (KF)	≤ 5.0%
Single-Chain Proportion (HPLC)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.