Description

Neridronate Sodium Hydrate is a high-purity bisphosphonate compound, a class of drugs known for their potent affinity for bone mineral. This material is a critical active pharmaceutical ingredient (API) and a key intermediate in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing and producing treatments for bone metabolism disorders, including osteoporosis and Paget's disease.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in injectable formulations for the treatment of bone-related diseases.
• Osteoporosis Treatment: Key component in medications designed to inhibit bone resorption and increase bone mineral density.
• Paget's Disease of Bone: Used in therapeutic agents to manage this chronic skeletal disorder.
• Oncology Supportive Care: Research and development for mitigating bone complications associated with certain cancers and their treatments.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Biochemical Research: Used in studies investigating bone metabolism, osteoclast inhibition, and calcium regulation pathways.
• Veterinary Medicine: Potential application in developing treatments for bone disorders in animals.

Basic Information

Product Name	Neridronate Sodium Hydrate
CAS No.	79778-41-9
Molecular Formula	C7H16NNaO7P2 · xH2O
Molecular Weight	Anhydrous: 311.14 g/mol
Synonyms	Neridronic Acid Sodium Salt Hydrate; Neridronate Disodium Hydrate; (6-Amino-1-hydroxy-1-phosphonohexyl)phosphonic Acid Sodium Salt Hydrate; Sodium Neridronate Hydrate; Nerixia; BN 021; Aminohexane Bisphosphonate Sodium Salt
EINECS	Contact for details

Quality Control

Our Neridronate Sodium Hydrate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, purity, and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 10.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
pH (1% Solution)	6.0 - 8.0
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.