Description

Iotrolan CAS NO 79770-24-4 is a non-ionic, dimeric, iso-osmolar contrast medium belonging to the class of iodinated compounds. Its primary value lies in its excellent water solubility and favorable safety profile, making it a critical component for high-quality diagnostic imaging. This product is essential for manufacturers in the pharmaceutical and medical device industries, particularly for formulating X-ray and computed tomography (CT) contrast agents used in myelography, angiography, and other specialized radiological procedures.

Application

• X-ray Contrast Media: Primary active ingredient in formulations for diagnostic imaging.
• Myelography: Used in contrast agents for imaging the spinal canal and subarachnoid space.
• Angiography: Key component in vascular contrast agents for visualizing blood vessels.
• Computed Tomography (CT): Utilized in contrast-enhanced CT scans for improved tissue differentiation.
• Arthrography: Employed in joint imaging procedures.
• Pharmaceutical Intermediates: Serves as a high-purity building block for advanced contrast media synthesis.
• Research & Development: Used in academic and industrial labs for developing new diagnostic agents.

Basic Information

Product Name	Iotrolan
CAS No.	79770-24-4
Molecular Formula	C37H48I6N6O15
Molecular Weight	1626.23 g/mol
Synonyms	Iotrolan; Iotrol; ZK 39482; Isovist; Iotrolanum; 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide]; Non-ionic dimeric contrast medium
EINECS	Contact for details

Quality Control

Our Iotrolan is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. Quality is assured through rigorous in-process and final release testing, which includes identification, assay, impurity profiling, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing compliance with agreed specifications. We support compliance with major pharmacopoeial standards (e.g., USP, EP) and cGMP principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
pH (in solution)	6.5 - 7.5
Osmolality	Approx. 300 mOsm/kg (in typical formulation)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.