Description

n-Boc-L-Ala-Nhobn is a protected amino acid derivative, specifically an N-Boc-L-alanine active ester, widely used in peptide synthesis. This compound is a critical building block for the controlled and efficient formation of peptide bonds, offering high coupling efficiency and minimal racemization. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of peptide-based therapeutics, diagnostics, and research reagents. Its reliable performance makes it a cornerstone for advanced solid-phase and solution-phase peptide synthesis workflows.

Application

• Peptide Synthesis: A key intermediate for the controlled incorporation of L-alanine residues in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Used in the synthesis of peptide tags, linkers, and probes for labeling proteins and other biomolecules.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for drug discovery and high-throughput screening.
• Academic & Industrial Research: Fundamental reagent for studying peptide structure, function, and for developing novel synthetic methodologies.
• Custom Oligopeptide Production: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences.

Basic Information

Product Name	n-Boc-L-Ala-Nhobn
CAS No.	79722-09-1
Molecular Formula	C15H20N2O5
Molecular Weight	308.33 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-alanine 4-nitrobenzyl ester; Boc-L-Ala-ONb; Boc-L-Alanine 4-nitrobenzyl ester; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]propanoic acid 4-nitrobenzyl ester; tert-Butyloxycarbonyl-L-alanine p-nitrobenzyl ester; Boc-Ala-ONb; L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, 4-nitrophenylmethyl ester; Boc-L-Ala-O-4-NO2-Bzl
EINECS	Contact for details

Quality Control

Our n-Boc-L-Ala-Nhobn is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and loss on drying. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-20° to -25° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.