Description

3-[3-(125I)Iodophenyl]-3-(Trifluoromethyl)Diaziridine is a specialized photoaffinity labeling reagent containing a radioactive iodine-125 isotope and a reactive diazirine group. This compound is critical for advanced biochemical research, enabling the covalent cross-linking and identification of transient or low-affinity biomolecular interactions. It is primarily utilized by research institutions and pharmaceutical R&D departments for proteomics, target identification, and drug discovery studies.

Application

• Photoaffinity Labeling in Proteomics: Used to covalently tag and identify protein targets and binding sites.
• Drug Discovery & Target Identification: Essential for mapping the interaction sites of novel drug candidates with their biological targets.
• Biomolecular Interaction Studies: Investigates protein-protein, protein-ligand, and protein-nucleic acid interactions.
• Radioligand Binding Assays: Serves as a high-specific-activity tracer for sensitive receptor binding studies.
• Structural Biology Research: Aids in the study of complex molecular structures and dynamics.
• Chemical Biology Tool Development: Employed in the synthesis of advanced probes for functional genomics.

Basic Information

Product Name	3-[3-(125I)Iodophenyl]-3-(Trifluoromethyl)Diaziridine
CAS No.	79684-36-9
Molecular Formula	C9H6F3IN2 (Non-radioactive analogue)
Molecular Weight	Contact for details
Synonyms	3-(3-(125I)Iodophenyl)-3-(trifluoromethyl)diaziridine; 3-[3-(I-125)Iodophenyl]-3-(trifluoromethyl)diaziridine; (125I)TID; Radioiodinated TID; 3-(3-Iodophenyl)-3-(trifluoromethyl)diaziridine (I-125); Photoaffinity Labeling Reagent (125I); Diazirine-125I Probe; Aryl Diazirine-125I
EINECS	Contact for details

Quality Control

Every batch of 3-[3-(125I)Iodophenyl]-3-(Trifluoromethyl)Diaziridine is produced and tested under strict quality management systems. Radiochemical purity and specific activity are rigorously verified using analytical techniques such as radio-HPLC and TLC to ensure consistency and performance for critical research applications. A comprehensive Certificate of Analysis (COA), detailing radionuclidic purity, radiochemical purity, specific activity, and solvent composition, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. This product is light-sensitive (store away from light) and should be handled in accordance with all applicable radiation safety regulations. Use appropriate shielding.

Specification

Item	Specification
Appearance	Clear colorless to pale yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (RCP)	≥ 95%
Specific Activity	Contact for details
Solvent	Ethanol or other specified solvent
Concentration	1.0 mCi/mL (typical, as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.