Description

Disuccinimidyl Glutarate is a homobifunctional N-hydroxysuccinimide (NHS) ester crosslinker widely used in bioconjugation and protein chemistry. This compound matters for its ability to efficiently form stable amide bonds between primary amines under mild aqueous conditions, enabling the study of protein interactions and the development of diagnostic and therapeutic agents. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications such as antibody-drug conjugate (ADC) development, peptide synthesis, and the preparation of immobilized enzymes.

Application

• Crosslinking agent for the conjugation of proteins, peptides, and antibodies.
• Key reagent in the synthesis of antibody-drug conjugates (ADCs) and other biopharmaceuticals.
• Preparation of hapten-carrier protein conjugates for immunoassay and vaccine development.
• Immobilization of biomolecules onto solid supports (e.g., resins, chips, beads) for biosensors and affinity chromatography.
• Proteomics research, including the study of protein-protein interactions and complex formation.
• Modification of amine-containing polymers and nanomaterials for advanced material science applications.

Basic Information

Product Name	Disuccinimidyl Glutarate
CAS No.	79642-50-5
Molecular Formula	C13H14N2O8
Molecular Weight	326.26 g/mol
Synonyms	N,N'-Disuccinimidyl glutarate; DSG; Glutaric acid bis(2,5-dioxopyrrolidin-1-yl) ester; Bis(N-succinimidyl) glutarate; 1,5-Bis(2,5-dioxo-1-pyrrolidinyl) pentanedioate; Glutaric acid di(N-succinimidyl) ester; DSC (Note: often confused with Disuccinimidyl Carbonate); NHS-Glutarate
EINECS	Contact for details

Quality Control

Our Disuccinimidyl Glutarate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation. For long-term storage, consider desiccant and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.