Description

Neuronal Bungarotoxin CAS NO 79633-24-2 is a highly purified, long-chain neurotoxin isolated from the venom of the banded krait (*Bungarus multicinctus*). This compound is a critical pharmacological tool for the selective and irreversible blockade of postsynaptic nicotinic acetylcholine receptors (nAChRs), specifically the α7 and muscle-type subtypes. It is essential for neuroscience research, enabling the study of receptor function, synaptic transmission, and neuromuscular junction biology. Researchers in academic institutions, pharmaceutical R&D, and biotechnology companies rely on this high-purity toxin for electrophysiology, binding assays, and the development of neurological disease models.

Application

• Neuroscience Research: Selective inhibition of neuronal α7 and muscle-type nicotinic acetylcholine receptors in electrophysiological studies.
• Pharmacological Studies: Used as a specific antagonist to characterize receptor subtypes and screen for novel cholinergic compounds.
• Synaptic Physiology: Investigation of synaptic plasticity, neurotransmission, and neuromuscular junction function.
• Toxin-Receptor Interaction Studies: Fundamental research on the mechanism of action of neurotoxic peptides.
• Drug Discovery: Target validation and assay development for conditions involving nAChRs, such as cognitive disorders and myasthenic syndromes.
• Biological Standard: Serves as a reference standard in analytical and bioassay laboratories for quality control of related products.

Basic Information

Product Name	Neuronal Bungarotoxin
CAS No.	79633-24-2
Molecular Formula	CnHnNnOnSn (Contact for details)
Molecular Weight	~7800-8000 Da (Contact for details)
Synonyms	κ-Bungarotoxin; Bungarotoxin 3.1; Neuronal Bungarotoxin α; Toxin F; Long-chain Neurotoxin 3; κ-Bgt; κ-BTX; BGT-3.1; Nicotinic Acetylcholine Receptor Antagonist (α7 selective)
EINECS	Contact for details

Quality Control

Our Neuronal Bungarotoxin is produced and handled under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and biological activity assays to confirm specific receptor blockade potency. A detailed Certificate of Analysis (COA) is provided, documenting purity, potency, and safety data (e.g., endotoxin levels). Our quality system is designed to meet the rigorous demands of life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot into working solutions to avoid repeated freeze-thaw cycles. Handle in accordance with good laboratory practice for toxic substances.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (Assay)	≥ 95% (Specific receptor blockade)
Protein Content (BCA)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers (e.g., PBS)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.