Description

Neocarzinostatin Chromophore A is the active, non-protein chromophore component of the potent antitumor antibiotic Neocarzinostatin. This compound is critical for its ability to cause DNA strand scission, making it a valuable tool in biochemical research and a model for novel anticancer agent development. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on oncology, DNA damage mechanisms, and the synthesis of enediyne-based therapeutics.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of DNA cleavage mechanisms and enediyne chemistry.
• Anticancer Agent Development: Serves as a core structural model for the design and synthesis of novel enediyne-based chemotherapeutic compounds.
• Mechanistic Studies: Employed to investigate cellular apoptosis pathways and the biological response to targeted DNA damage.
• Pharmaceutical Intermediates: Acts as a key intermediate or precursor in the research-scale synthesis of complex antitumor molecules.
• Academic Research: Utilized in university laboratories for teaching and advanced research in medicinal chemistry and molecular pharmacology.

Basic Information

Product Name	Neocarzinostatin Chromophore A
CAS No.	79633-18-4
Molecular Formula	C₃₅H₃₅NO₁₂
Molecular Weight	661.66 g/mol
Synonyms	NCS Chromophore A; Neocarzinostatin Chromophore; (1S,6R,7S,8S)-8-[(2S)-2-Acetamido-2-carboxyethyl]sulfanyl-7-[(2R,3S)-3,4-dihydroxy-2-methylbut-3-enoyl]oxy-6-hydroxy-5,8,11-trioxatricyclo[6.4.0.0²,⁶]dodeca-2,4,9-trien-3-one; NCS-CA; NCS Chromophore
EINECS	Contact for details

Quality Control

Our Neocarzinostatin Chromophore A is produced and handled under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.