Description

(5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-Eicosatetraenoic Acid CAS NO 79516-82-8 is a specialized eicosanoid derivative, a member of the hydroxyeicosatetraenoic acid (HETE) family, known for its distinct stereochemistry and conjugated tetraene structure. This compound is of significant interest for its role as a bioactive lipid mediator in advanced biochemical and pharmacological research. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for investigating inflammatory pathways, cell signaling mechanisms, and as a reference standard for analytical method development.

Application

• Biochemical Research: Used as a high-purity reference standard and analytical reagent in lipidomics and eicosanoid research.
• Pharmaceutical R&D: Serves as a key intermediate or active metabolite in the development of novel anti-inflammatory and immunomodulatory drugs.
• Cell Signaling Studies: Employed to study specific receptor-ligand interactions and downstream signaling cascades related to inflammation and immune response.
• Metabolic Pathway Analysis: A critical tool for elucidating the arachidonic acid metabolic pathway and the biological activity of its hydroxylated derivatives.
• Diagnostic Development: Used in the calibration and validation of diagnostic assays targeting specific lipid mediators in biological samples.

Basic Information

Product Name	(5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-Eicosatetraenoic Acid
CAS No.	79516-82-8
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	5(S),12(R),20-Trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; 5,12,20-TriHETE; (5S,12R)-5,12,20-TriHETE; 5,12,20-Trihydroxyeicosatetraenoic acid; 5,12,20-Trihydroxy-6,8,10,14-eicosatetraenoic acid; Lipoxin/Resolvin analogue; Polyhydroxylated eicosanoid
EINECS	Contact for details

Quality Control

Our (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-Eicosatetraenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.