Description

2',3'-o-(1-(2-Carboxyethyl)Ethylidene)-7-Methylguanosine 5'-Diphosphate is a chemically modified nucleotide derivative, specifically a guanosine analog with a unique caged or protected structure. This compound is of significant value in biochemical and pharmaceutical research as a precursor or intermediate for synthesizing modified RNA molecules and for studying nucleotide-dependent enzymatic processes. It is primarily needed by research institutions, biotechnology companies, and pharmaceutical developers engaged in advanced nucleic acid chemistry, probe development, and drug discovery programs.

Application

• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies of kinases, polymerases, and other nucleotide-binding proteins.
• Nucleic Acid Probe Synthesis: Serves as a key building block for creating fluorescently labeled or otherwise modified RNA probes for diagnostics and imaging.
• Pharmaceutical Intermediate: Acts as a critical synthetic intermediate in the development of nucleotide-based therapeutics, including antiviral and anticancer agents.
• Mechanistic Studies: Employed to investigate the structure-activity relationships and metabolic pathways of modified nucleosides and nucleotides.
• Cross-linking Studies: The reactive ethylidene and carboxyethyl groups can be utilized for cross-linking experiments to study RNA-protein interactions.

Basic Information

Product Name	2',3'-o-(1-(2-Carboxyethyl)Ethylidene)-7-Methylguanosine 5'-Diphosphate
CAS No.	79441-42-2
Molecular Formula	C₂₀H₂₈N₅O₁₇P₂
Molecular Weight	672.41 g/mol
Synonyms	7-Methyl-GDP derivative; 2',3'-O-(1-Carboxyethylidene)-7-methylguanosine 5'-diphosphate; caged 7-Methylguanosine diphosphate; 7-Me-GDP cyclic acetal; 79441-42-2; Modified GDP analog; Nucleotide research chemical; Guanosine-5'-diphosphate, 2',3'-O-(1-(2-carboxyethyl)ethylidene)-7-methyl-
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical adheres to stringent quality protocols. Every batch is characterized and tested to ensure identity, purity, and stability, with specifications typically meeting or exceeding research-grade standards. A comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and MS analysis is provided with each shipment to guarantee traceability and support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere to maintain stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.