Description

Enkephalin-Leu, Arg(6)-Phe(7)- is a synthetic peptide analog of the endogenous opioid peptide enkephalin, featuring specific amino acid substitutions at positions 6 and 7. This modification is designed to enhance its stability and receptor binding affinity, making it a valuable tool for advanced neuroscience and pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers investigating pain modulation, neuropsychiatric disorders, and novel therapeutic pathways.

Application

• Neuroscience Research: As a key reagent for studying opioid receptor (e.g., delta and mu) signaling, function, and distribution in the central nervous system.
• Pharmacological Assay Development: Used in high-throughput screening (HTS) and binding assays to identify and characterize new analgesic or neuroprotective compounds.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand the impact of specific amino acid residues on peptide bioactivity and metabolic stability.
• Reference Standard: Serves as a high-purity analytical standard for quality control in peptide synthesis and for calibrating analytical instruments like HPLC and LC-MS.
• Drug Discovery Pipeline: A critical intermediate or lead compound in the development of next-generation, non-addictive pain therapeutics and neuropharmaceuticals.

Basic Information

Product Name	Enkephalin-Leu, Arg(6)-Phe(7)-
CAS No.	79358-92-2
Molecular Formula	C36H52N10O8
Molecular Weight	752.87 g/mol
Synonyms	[Arg6, Phe7]-Leu-Enkephalin; Leu-Enkephalin, [Arg6,Phe7]-; H-Tyr-Gly-Gly-Phe-Leu-Arg-Phe-OH; (5-L-Leucine,7-L-phenylalanine)-[Arg6]enkephalin; Opioid peptide analog; LE-Arg6-Phe7; Research peptide 79358-92-2
EINECS	Contact for details

Quality Control

Our Enkephalin-Leu, Arg(6)-Phe(7)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.