Description

(6R-Trans)-7-[[(2-Amino-4-Thiazolyl)Acetyl]Amino]-3-Ethenyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a key advanced pharmaceutical intermediate with a complex β-lactam core structure. This compound is critical for the synthesis of next-generation cephalosporin antibiotics, offering a pathway to molecules with enhanced efficacy and resistance profiles. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on developing novel anti-infective therapies.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate in the production of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and synthesis of new β-lactam derivatives with improved antibacterial activity.
• Process Chemistry & Scale-Up: Serves as a critical building block for process optimization and pilot-scale manufacturing of antibiotic candidates.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Used in studies investigating the mechanism of action and bacterial resistance to β-lactam antibiotics.

Basic Information

Product Name	(6R-Trans)-7-[[(2-Amino-4-Thiazolyl)Acetyl]Amino]-3-Ethenyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	79350-10-0
Molecular Formula	C14H14N4O4S2
Molecular Weight	366.42 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (common isomer name); 7-ACA Derivative; 3-Vinyl-3-cephem-4-carboxylic Acid Derivative; Cefixime Intermediate; Cephalosporin C-7 Side Chain Intermediate; ATAA; (6R-trans)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, O-Methyloxime
EINECS	Contact for details

Quality Control

This pharmaceutical intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for API synthesis. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory (e.g., ICH Q7, GMP) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.