Description

(3A,5B,7A)-24-[(Carboxymethyl)Amino]-7-Hydroxy-24-Oxocholan-3-Yl B-D-Glucopyranosiduronic Acid CAS NO 79254-98-1 is a high-purity, bile acid-derived chemical conjugate, specifically a glycine-conjugated bile acid glucuronide. This compound is of significant interest in advanced pharmaceutical research and development, particularly for studying bile acid metabolism, drug detoxification pathways, and as a reference standard for analytical methods. It is primarily utilized by research institutions, pharmaceutical companies, and diagnostic manufacturers engaged in hepatobiliary research, metabolite identification, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for quantitative analysis in drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolite Research: Critical for investigating Phase II detoxification pathways, specifically glucuronidation, of bile acids and related steroidal compounds.
• Diagnostic Development: Serves as a key calibrant or control in the development of clinical diagnostic assays for liver function and cholestatic diseases.
• Biochemical Research: Employed in enzymatic studies to understand the activity of UDP-glucuronosyltransferases (UGTs) and other conjugating enzymes.
• Analytical Method Validation: Essential for developing and validating sensitive analytical methods such as LC-MS/MS and HPLC for the detection of conjugated bile acids in biological matrices.

Basic Information

Item	Detail
Product Name	(3A,5B,7A)-24-[(Carboxymethyl)Amino]-7-Hydroxy-24-Oxocholan-3-Yl B-D-Glucopyranosiduronic Acid
CAS No.	79254-98-1
Molecular Formula	C32H49NO11
Molecular Weight	623.74 g/mol
Synonyms	Glycochenodeoxycholic Acid 3-O-Glucuronide; Glycochenodeoxycholate 3-Glucuronide; 3α-Glucuronyl-glycochenodeoxycholic Acid; GCDCA-3G; 3-Glucuronidyl-glycochenodeoxycholic Acid; N-(3α,7α-Dihydroxy-24-oxo-5β-cholan-24-yl)glycine 3-O-β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Every batch of (3A,5B,7A)-24-[(Carboxymethyl)Amino]-7-Hydroxy-24-Oxocholan-3-Yl B-D-Glucopyranosiduronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as assay purity (by HPLC), identity confirmation (by NMR/MS), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.