Description

Prothrombin Residue (1-39) is a defined peptide fragment derived from the N-terminal region of human prothrombin, a key zymogen in the blood coagulation cascade. This high-purity synthetic peptide is critical for advanced biochemical research and diagnostic development, serving as a precise tool for studying enzyme activation mechanisms and substrate specificity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and in vitro diagnostic (IVD) manufacturers focused on hemostasis and thrombosis.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in enzymatic studies to investigate the kinetics and regulation of thrombin generation and coagulation Factor Xa.
• Diagnostic Reagent Development: Serves as a key component in the formulation of calibrators, controls, and assay buffers for clinical diagnostic tests measuring prothrombin time (PT) and other coagulation parameters.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) assays to identify and characterize novel anticoagulant or procoagulant drug candidates.
• Antibody Production & Epitope Mapping: Acts as an immunogen for generating specific antibodies against the prothrombin fragment, useful for immunoassays and structural biology studies.
• Quality Control Reference Standard: Provides a defined molecular standard for quality assurance in the production of therapeutic proteins related to blood coagulation.

Basic Information

Product Name	Prothrombin Residue (1-39)
CAS No.	79177-29-0
Molecular Formula	C185H294N56O55S2
Molecular Weight	4230.8 g/mol
Synonyms	Prothrombin Fragment 1-39; Prothrombin (1-39); Human Prothrombin Residues 1-39; Prothrombin Activation Fragment 1; F1.39; Gla-domain peptide of prothrombin; Prethrombin 1 Fragment; PT (1-39)
EINECS	Contact for details

Quality Control

Our Prothrombin Residue (1-39) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are provided to ensure compliance with research and diagnostic-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.